AUTHOR=Shi Jia , Tang Mingwei , Zhou Shuang , Xu Dong , Zhao Jiuliang , Wu Chanyuan , Wang Qian , Tian Xinping , Li Mengtao , Zeng Xiaofeng 

TITLE=Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.783616

DOI=10.3389/fimmu.2021.783616

ISSN=1664-3224

ABSTRACT=<p>Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of acquired, autoimmune muscle diseases characterized by muscle inflammation and extramuscular involvements. Present literatures have revealed that dysregulated cell death in combination with impaired elimination of dead cells contribute to the release of autoantigens, damage-associated molecular patterns (DAMPs) and inflammatory cytokines, and result in immune responses and tissue damages in autoimmune diseases, including IIMs. This review summarizes the roles of various forms of programmed cell death pathways in the pathogenesis of IIMs and provides evidence for potential therapeutic targets.</p>