AUTHOR=Martín Diana , Perdiguero Pedro , Morel Esther , Soleto Irene , Herranz-Jusdado J. German , Ramón Luis A. , Abós Beatriz , Wang Tiehui , Díaz-Rosales Patricia , Tafalla Carolina TITLE=CD38 Defines a Subset of B Cells in Rainbow Trout Kidney With High IgM Secreting Capacities JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.773888 DOI=10.3389/fimmu.2021.773888 ISSN=1664-3224 ABSTRACT=
CD38 is a multifunctional molecule that functions both as a transmembrane signaling receptor and as an ectoenzyme with important roles in cell adhesion, calcium regulation and signal transduction. Within the B cell linage, CD38 is expressed in diverse murine B cell subsets, with highest levels in innate B cell subpopulations such as marginal zone (MZ) B cells or B1 cells. In humans, however, CD38 is transiently expressed on early lymphocyte precursors, is lost on mature B cells and is consistently expressed on terminally differentiated plasma cells. In the present work, we have identified two homologues of mammalian CD38 in rainbow trout (