AUTHOR=Sherwood Karen R. , Nicholl David D. M. , Fenninger Franz , Wu Vivian , Wong Paaksum , Benedicto Vince , Cina Davide P. , Wang Meng , Pobran Taylor D. , De Marco Mari L. , Márquez Anna Citlali , Jassem Agatha N. , Sekirov Inna , Morshed Muhammad G. , Bardi Mohammad , Sekhon Mypinder , Keown Paul , Kadatz Matthew , Lan James H. TITLE=Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.753558 DOI=10.3389/fimmu.2021.753558 ISSN=1664-3224 ABSTRACT=

To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.