Corrigendum: The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice

A Corrigendum on
The GABA_A Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice

by Bu J, Huang S, Wang J, Xia T, Liu H, You Y, Wang Z and Liu K (2021). Front. Immunol. 12:670153. doi: 10.3389/fimmu.2021.670153

In the original article, there was a mistake in Figure 3A and Supplement 3 as published. In the Figure 3A, the bicuculine group at day 28 post-TAC was inadvertently saved in the improper folders and attached to Sham group at days 14 and 28 post-TAC, so the representative images of Sham group at days 14 and 28 post-TAC were wrong and duplicated. In the Supplement 3, the representative image of Sham group at day 21 post-TAC was chosen by mistake. The corrected Figure 3A and Supplement 3 appear below.

FIGURE 3

Figure 3 Activation or blockade of the GABA_A receptor selectively increases or reduces the number of Ly6C^low macrophages in the hearts of pressure-overload hypertrophy mice. Macrophage (CD45⁺F4/80⁺CD11b⁺) subpopulations were respectively defined as Ly6C^high or Ly6C^low macrophages according to Ly-6C expression levels. (A) Representative images of Ly6C^high and Ly6C^low macrophages at days 7, 14, and 28 post-TAC. The representative images of 1, 3, and 21 days after TAC were shown in supplementary materials. (B) The number of Ly6C^low macrophages or Ly6C^high macrophages (per mg heart tissue) among the total number of live cells isolated from hearts at the indicated time points after TAC. (C) The number of CD45⁺CD11b⁺F4/80⁺EdU⁺cell (per mg heart tissue) among the total number of live cells isolated from hearts at the indicated time points after TAC. (D) Representative images of Ki-67⁺ expression in Ly6C^low macrophages at day 7 post-TAC. (E) The percentage of Ki-67⁺ expression in Ly6C^low macrophages. Data show the mean ± SEM, by one-way ANOVA with Bonferroni’s multiple comparison test. For topiramate treatment, *P < 0.05 vs. vehicle. For bicuculline treatment, ^#P < 0.05 vs. vehicle. (n = 3 mice for sham group, n = 6–8 mice for all other groups).

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2021.753404/full#supplementary-material

Supplement 3 | Living cells (upper panel) were gated to determine the presence of CD45⁺Ly6G^-CD11b⁺Ly6C^high and CD45⁺Ly6G^-CD11b⁺Ly6C^low monocytes at day 21 post-TAC in the peripheral blood.