AUTHOR=Singh Anil K. , Haque Mahamudul , Madarampalli Bhanupriya , Shi Yuanyuan , Wildman Benjamin J. , Basit Abdul , Khuder Sadik A. , Prasad Bhagwat , Hassan Quamarul , Ouseph Madhu M. , Ahmed Salahuddin TITLE=Ets-2 Propagates IL-6 Trans-Signaling Mediated Osteoclast-Like Changes in Human Rheumatoid Arthritis Synovial Fibroblast JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.746503 DOI=10.3389/fimmu.2021.746503 ISSN=1664-3224 ABSTRACT=
Rheumatoid arthritis synovial fibroblasts (RASFs) contribute to synovial inflammation and bone destruction by producing a pleiotropic cytokine interleukin-6 (IL-6). However, the molecular mechanisms through which IL-6 propels RASFs to contribute to bone loss are not fully understood. In the present study, we investigated the effect of IL-6 and IL-6 receptor (IL-6/IL-6R)-induced trans-signaling in human RASFs. IL-6 trans-signaling caused a significant increase in tartrate-resistant acid phosphatase (TRAP)-positive staining in RASFs and enhanced pit formation by ~3-fold in the osteogenic surface