AUTHOR=Rijkers Ger T. , Riccardi Carlo , Kroese Frans G. M. TITLE=Editorial: Defects in Regulation: How, Where and When the Immune System Can Go Wrong JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.746418 DOI=10.3389/fimmu.2021.746418 ISSN=1664-3224