AUTHOR=Martin-Romano Patricia , Adam Julien , Scoazec Jean-Yves , Gouy Sébastien , Levy Antonin , Baldini Capucine , Champiat Stéphane , Soria Jean-Charles , Massard Christophe , Marabelle Aurélien , Deutsch Eric , Hollebecque Antoine 

TITLE=Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.745146

DOI=10.3389/fimmu.2021.745146

ISSN=1664-3224

ABSTRACT=<p>Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.</p>