AUTHOR=Jacob-Nascimento Leile Camila , Carvalho Caroline Xavier , Silva Monaíse Madalena Oliveira , Kikuti Mariana , Anjos Rosângela Oliveira , Fradico Jordana Rodrigues Barbosa , Campi-Azevedo Ana Carolina , Tauro Laura Beatriz , Campos Gúbio Soares , Moreira Patricia Sousa dos Santos , Portilho Moyra Machado , Martins-Filho Olindo Assis , Ribeiro Guilherme Sousa , Reis Mitermayer Galvão TITLE=Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.744183 DOI=10.3389/fimmu.2021.744183 ISSN=1664-3224 ABSTRACT=
The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months