AUTHOR=Zhou Hao , Ma Long , Liu Longyu , Yao Xinsheng 

TITLE=TR Locus Annotation and Characteristics of Rhinolophus ferrumequinum

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.741408

DOI=10.3389/fimmu.2021.741408

ISSN=1664-3224

ABSTRACT=<p>T-cell antigen receptors (TRs) in vertebrates can be divided into αβ or γδ, encoded by TRA/D, TRG, or TRB loci. TRs play a central role in mammal cellular immunity, which occurs by rearrangement of V, D, J, and C genes in the loci. The bat is the only mammal with flying ability and is considered the main host of zoonotic viruses, an important public health concern. However, at present, little is known about the composition of bat TR genes. Based on the whole genome sequence of the greater horseshoe bat (<italic>Rhinolophus ferrumequinum</italic>) and referring to the TR/IG annotation rules formulated by the international ImMunoGeneTics information system (IMGT), we present a complete annotation of TRA/D, TRG, and TRB loci of <italic>R. ferrumequinum</italic>. A total of 128 V segments, three D segments, 85 J segments, and 6 C segments were annotated and compared with other known mammalian data. The characteristics of the TR locus and germline genes of <italic>R. ferrumequinum</italic> are analyzed.</p>