AUTHOR=Zhai Guang-hua , Zhang Wei , Xiang Ze , He Li-Zhen , Wang Wei-wei , Wu Jian , Shang An-quan 

TITLE=Diagnostic Value of sIL-2R, TNF-α and PCT for Sepsis Infection in Patients With Closed Abdominal Injury Complicated With Severe Multiple Abdominal Injuries

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.741268

DOI=10.3389/fimmu.2021.741268

ISSN=1664-3224

ABSTRACT=Objective: To evaluate the diagnostic value of soluble interleukin-2 receptor (sIL-2R), tumor necrosis factor-α (TNF-α), procalcitonin (PCT) and combined detection for sepsis infection in patients with closed abdominal injury complicated with severe multiple abdominal injuries.
Patients and Methods: 140 patients with closed abdominal injury complicated with severe multiple abdominal injuries who were diagnosed and treated in 2015 to 2020, were divided into sepsis group (n = 70), and infection group (n = 70).
Results: The levels of sIL-2R, TNF-α and PCT in sepsis group were higher than those in infection group (P < 0.05). ROC curve showed that the AUC values of sIL-2R, TNF-α, PCT and sIL-2R+TNF-a+PCT were 0.827, 0.781, 0.821 and 0.846, respectively, which were higher than those of WBC (0.712), CRP (0.766), SAA (0.666), and IL-6(0.735). AUC of the three combined tests was higher than that of TNF-α, and the difference was statistically significant (P < 0.05). There was no significant difference in AUC between sIL-2R and TNF-α, sIL-2R and PCT, TNF-α and PCT, three combined tests and sIL-2R, three combined tests and PCT (P > 0.05). When the median was used as the cut point, the corrected sIL-2R, TNF-α, PCT high level group was not better than the low level group (P >0.05). When the four groups were classified by using quantile as cut point, the OR risk values of the high level of TNF-α and PCT (Q4) and the low level of PCT (Q1) after correction were 7.991 and 21.76, respectively, with statistical significance (P < 0.05).
Conclusions: The detection of sIL-2R, TNF-α and PCT has a good value in the diagnosis for sepsis infection in patients with closed abdominal injury complicated with severe multiple abdominal injuries. The high concentrations of PCT and TNF-α can be used as predictors of septic infection risk.