AUTHOR=Ssemaganda Aloysious , Cholette Francois , Perner Michelle , Kambaran Cheli , Adhiambo Wendy , Wambugu Peter M. , Gebrebrhan Henok , Lee Amy , Nuhu Faisal , Mwatelah Ruth S. , Jahan Naima , Omole Tosin E. , Wanjiru Tabitha , Gitau Apollo , Kimani Joshua , McKinnon Lyle R. TITLE=Endocervical Regulatory T Cells Are Associated With Decreased Genital Inflammation and Lower HIV Target Cell Abundance JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.726472 DOI=10.3389/fimmu.2021.726472 ISSN=1664-3224 ABSTRACT=
Regulatory T cells (Tregs) play important roles in tissue homeostasis, but few studies have investigated tissue Tregs in the context of genital inflammation, HIV target cell density, and vaginal microbiota in humans. In women from Nairobi (n=64), the proportion of CD4+ CD25+ CD127low Tregs in the endocervix correlated with those in blood (r=0.31, p=0.01), with a higher Treg frequency observed in the endocervix (median 3.8