AUTHOR=Kaur Arvinpreet , Chopra Mehak , Bhushan Mahak , Gupta Sonal , Kumari P Hima , Sivagurunathan Narmadhaa , Shukla Nidhi , Rajagopal Shalini , Bhalothia Purva , Sharma Purnima , Naravula Jalaja , Suravajhala Renuka , Gupta Ayam , Abbasi Bilal Ahmed , Goswami Prittam , Singh Harpreet , Narang Rahul , Polavarapu Rathnagiri , Medicherla Krishna Mohan , Valadi Jayaraman , Kumar S Anil , Chaubey Gyaneshwer , Singh Keshav K. , Bandapalli Obul Reddy , Kavi Kishor Polavarapu Bilhan , Suravajhala Prashanth TITLE=The Omic Insights on Unfolding Saga of COVID-19 JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.724914 DOI=10.3389/fimmu.2021.724914 ISSN=1664-3224 ABSTRACT=

The year 2019 has seen an emergence of the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease of 2019 (COVID-19). Since the onset of the pandemic, biological and interdisciplinary research is being carried out across the world at a rapid pace to beat the pandemic. There is an increased need to comprehensively understand various aspects of the virus from detection to treatment options including drugs and vaccines for effective global management of the disease. In this review, we summarize the salient findings pertaining to SARS-CoV-2 biology, including symptoms, hosts, epidemiology, SARS-CoV-2 genome, and its emerging variants, viral diagnostics, host-pathogen interactions, alternative antiviral strategies and application of machine learning heuristics and artificial intelligence for effective management of COVID-19 and future pandemics.