AUTHOR=Wahrmann Markus , Döhler Bernd , Arnold Marie-Luise , Scherer Sabine , Mayer Katharina A. , Haindl Susanne , Haslacher Helmuth , Böhmig Georg A. , Süsal Caner 

TITLE=Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.724331

DOI=10.3389/fimmu.2021.724331

ISSN=1664-3224

ABSTRACT=<p>The functional Fc gamma receptor (FcγR) IIIA polymorphism <italic>FCGR3A</italic>-V/F158 was earlier suggested to determine the potential of donor-specific HLA antibodies to trigger microcirculation inflammation, a key lesion of antibody-mediated renal allograft rejection. Associations with long-term transplant outcomes, however, have not been evaluated to date. To clarify the impact of <italic>FCGR3A</italic>-V/F158 polymorphism on kidney transplant survival, we genotyped a cohort of 1,940 recipient/donor pairs. Analyzing 10-year death-censored allograft survival, we found no significant differences in relation to <italic>FCGR3A</italic>-V/F158. There was also no independent survival effect in a multivariable Cox model. Similarly, functional polymorphisms in two other activating FcγR, <italic>FCGR2A</italic>-H/R131 (FcγRIIA) and <italic>FCGR3B</italic>-NA1/NA2 (FcγRIIIB), were not associated with outcome. There were also no significant survival differences among patient subgroups at increased risk of rejection-related injury, such as pre-sensitized recipients (&gt; 0% panel reactivity; n = 438) or recipients treated for rejection within the first year after transplantation (n = 229). Our study results suggest that the earlier shown association of FcγR polymorphism with microcirculation inflammation may not be strong enough to exert a meaningful effect on graft survival.</p>