AUTHOR=Bošnjak Berislav , Odak Ivan , Ritter Christiane , Stahl Klaus , Graalmann Theresa , Steinbrück Lars , Blasczyk Rainer , Falk Christine S. , Schulz Thomas F. , Wedemeyer Hans Heinrich , Cornberg Markus , Ganser Arnold , Förster Reinhold , Koenecke Christian TITLE=Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.721738 DOI=10.3389/fimmu.2021.721738 ISSN=1664-3224 ABSTRACT=

Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.