AUTHOR=Yoo Sun Koo , Mehdi Syed Faizan , Pusapati Suma , Mathur Nimisha , Anipindi Manasa , Lunenfeld Bruno , Lowell Barbara , Yang Huan , Metz Christine Noel , Khan Sawleha Arshi , Leroith Derek , Roth Jesse TITLE=Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.714177 DOI=10.3389/fimmu.2021.714177 ISSN=1664-3224 ABSTRACT=

Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.