AUTHOR=Kwarteng Alexander , Asiedu Ebenezer , Koranteng Kelvin Kwaku , Asiedu Samuel Opoku 

TITLE=Highlighting the Relevance of CD8+ T Cells in Filarial Infections

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.714052

DOI=10.3389/fimmu.2021.714052

ISSN=1664-3224

ABSTRACT=<p>The T cell immune responses in filarial infections are primarily mediated by CD4<sup>+</sup> T cells and type 2-associated cytokines. Emerging evidence indicates that CD8<sup>+</sup> T cell responses are important for anti-filarial immunity, however, could be suppressed in co-infections. This review summarizes what we know so far about the activities of CD8<sup>+</sup> T cell responses in filarial infections, co-infections, and the associations with the development of filarial pathologies.</p>