AUTHOR=Sánchez-Salguero Erick , Corona-Cervantes Karina , Guzmán-Aquino Hector Armando , de la Borbolla-Cruz María Fernanda , Contreras-Vargas Víctor , Piña-Escobedo Alberto , García-Mena Jaime , Santos-Argumedo Leopoldo TITLE=Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.712130 DOI=10.3389/fimmu.2021.712130 ISSN=1664-3224 ABSTRACT=
Microbiota acquired during labor and through the first days of life contributes to the newborn’s immune maturation and development. Mother provides probiotics and prebiotics factors through colostrum and maternal milk to shape the first neonatal microbiota. Previous works have reported that immunoglobulin A (IgA) secreted in colostrum is coating a fraction of maternal microbiota. Thus, to better characterize this IgA-microbiota association, we used flow cytometry coupled with 16S rRNA gene sequencing (IgA-Seq) in human colostrum and neonatal feces. We identified IgA bound bacteria (IgA+) and characterized their diversity and composition shared in colostrum fractions and neonatal fecal bacteria. We found that IgA2 is mainly associated with