AUTHOR=Zhou Xiaoli , Zhou Ya-Na , Ali Ashaq , Liang Cuiqin , Ye Zhiqin , Chen Xiaomin , Zhang Qing , Deng Lihua , Sun Xinyi , Zhang Qian , Luo Jihong , Li Wei , Zhou Kun , Cao Shanshan , Zhang Xiaowei , Li Xiao-Dong , Zhang Xian-En , Cui Zongqiang , Men Dong TITLE=Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.701295 DOI=10.3389/fimmu.2021.701295 ISSN=1664-3224 ABSTRACT=

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.