AUTHOR=Mazzarino Randall C. 

TITLE=Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.694300

DOI=10.3389/fimmu.2021.694300

ISSN=1664-3224

ABSTRACT=<p>We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. Viruses will hijack host cellular machinery, including metabolic processes. Here, I provide theory and evidence for targeting the host <italic>de novo</italic> purine synthetic pathway for broad spectrum anti-viral drug development as well as the pursuit of basic science to mitigate the risks of future novel viral outbreaks.</p>