AUTHOR=Fischer Joseph W. , Bhattarai Nirjal 

TITLE=CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.693016

DOI=10.3389/fimmu.2021.693016

ISSN=1664-3224

ABSTRACT=<p>Engineered T cell therapies such as chimeric antigen receptor (CAR) expressing T cells (CAR-T cells) have great potential to treat many human diseases; however, inflammatory toxicities associated with these therapies present safety risks and can greatly limit its widespread use. This article briefly reviews our current understanding of mechanisms for inflammatory toxicities during CAR T-cell therapy, current strategies for management and mitigation of these risks and highlights key areas of knowledge gap for future research.</p>