AUTHOR=Martins Ronchi Daiane Cristine , Scaranello Malaquias Mineia Alessandra , Rebutini Patrícia Zadorosnei , Panini do Carmo Letícia Arianne , Neto Plínio Cézar , Marini Emily Scaranello , Prokopenko Amanda , Nagashima Seigo , Zanluca Camila , Duarte dos Santos Claudia Nunes , de Noronha Lúcia TITLE=Placental Morphologic Similarities Between ZIKV-Positive and HIV-Positive Pregnant Women JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.684194 DOI=10.3389/fimmu.2021.684194 ISSN=1664-3224 ABSTRACT=
Zika virus (ZIKV) caused global concern due to Brazil's unexpected epidemic, and it was associated with congenital microcephaly and other gestational intercurrences. The study aimed to analyze the placenta morphometric changes of ZIKV-infected pregnant women (ZIKV group; n = 23) compared to placentas of HIV-infected (HIV group; n = 24) and healthy pregnant women (N-control group; n = 22). It also analyzed the relationship between the morphometric results and pathological alterations on conventional microscopy, gestational trimester of infection, and presence of the congenital Zika syndrome (CZS). There was a significant increase in area (