AUTHOR=Boudhabhay Idris , Rabant Marion , Roumenina Lubka T. , Coupry Louis-Marie , Poillerat Victoria , Marchal Armance , Frémeaux-Bacchi Véronique , El Karoui Khalil , Monchi Mehran , Pourcine Franck 

TITLE=Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.680567

DOI=10.3389/fimmu.2021.680567

ISSN=1664-3224

ABSTRACT=<sec><title>Background</title><p>The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown.</p></sec><sec><title>Case Presentation</title><p>We describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function.</p></sec><sec><title>Conclusion</title><p>Our case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option.</p></sec>