AUTHOR=Gingrich Alicia A. , Reiter Taylor E. , Judge Sean J. , York Daniel , Yanagisawa Mio , Razmara Aryana , Sturgill Ian , Basmaci Ugur Nur , Brady Rachel V. , Stoffel Kevin , Murphy William J. , Rebhun Robert B. , Brown C. Titus , Canter Robert J. TITLE=Comparative Immunogenomics of Canine Natural Killer Cells as Immunotherapy Target JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.670309 DOI=10.3389/fimmu.2021.670309 ISSN=1664-3224 ABSTRACT=
Natural killer (NK) cells are key effectors of the innate immune system, but major differences between human and murine NK cells have impeded translation. Outbred dogs offer an important link for studies of NK biology and immunotherapy. We analyzed gene expression of putative NK populations from healthy dogs and dogs with naturally-occurring cancers examining differential gene expression across multiple conditions, including steady-state,