AUTHOR=Renaude Elodie , Kroemer Marie , Borg Christophe , Peixoto Paul , Hervouet Eric , Loyon Romain , Adotévi Olivier 

TITLE=Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.669992

DOI=10.3389/fimmu.2021.669992

ISSN=1664-3224

ABSTRACT=<p>Evidences highlight the role of various CD4<sup>+</sup> helper T cells (CD4<sup>+</sup> Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4<sup>+</sup> Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4<sup>+</sup> T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4<sup>+</sup> Th responses by epigenetic drugs to improve anticancer immunotherapy.</p>