AUTHOR=Stefańska Katarzyna , Zieliński Maciej , Jankowiak Martyna , Zamkowska Dorota , Sakowska Justyna , Adamski Przemysław , Jassem-Bobowicz Joanna , Piekarska Karolina , Leszczyńska Katarzyna , Świątkowska-Stodulska Renata , Kwiatkowski Sebastian , Preis Krzysztof , Trzonkowski Piotr , Marek-Trzonkowska Natalia TITLE=Cytokine Imprint in Preeclampsia JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.667841 DOI=10.3389/fimmu.2021.667841 ISSN=1664-3224 ABSTRACT=

The hallmark of preeclampsia (PE) is a shift toward persistent inflammatory response, accompanied by endothelial dysfunction. The driving forces in PE are proinflammatory cytokine and growth factors, in parallel with reduced functionality of anti-inflammatory effectors, like regulatory T cells are observed. Unfortunately, no conclusive mechanism underlying preeclampsia has been identified. For this reason, research on preeclampsia is needed to provide a state of the art understanding of the pathophysiology, identification of new diagnostics tools and the development of targeted therapies. The 68 patients were divided into three groups: gestational hypertension (GH) group (n = 19) and PE group (n = 28) and a control group (n = 21). We have tested a set of 53 cytokines, chemokines and growth factors in preeclampsia and gestational hypertension, and then compared them with normal pregnancies. Using a diagnostic test assessment characteristic parameters (IL-22, MDC/CCL22, IL-2/IL-4 ratio) have been identified and cut-off values have been proposed to diagnose preeclampsia. All parameters had high negative or positive predictive values, above 80%. In conclusion, we have proposed a potential set of immune parameters to diagnose preeclampsia.