AUTHOR=Wei Li , Liu Kai , Jia Qingzhi , Zhang Hui , Bie Qingli , Zhang Bin 

TITLE=The Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.664787

DOI=10.3389/fimmu.2021.664787

ISSN=1664-3224

ABSTRACT=<p>Tuberculosis remains a major health problem. <italic>Mycobacterium tuberculosis</italic>, the causative agent of tuberculosis, can replicate and persist in host cells. Noncoding RNAs (ncRNAs) widely participate in various biological processes, including <italic>Mycobacterium tuberculosis</italic> infection, and play critical roles in gene regulation. In this review, we summarize the latest reports on ncRNAs (microRNAs, piRNAs, circRNAs and lncRNAs) that regulate the host response against <italic>Mycobacterium tuberculosis</italic> infection. In the context of host-<italic>Mycobacterium tuberculosis</italic> interactions, a broad and in-depth understanding of host ncRNA regulatory mechanisms may lead to potential clinical prospects for tuberculosis diagnosis and the development of new anti-tuberculosis therapies.</p>