AUTHOR=Miladinovic Milica , Wittekindt Boris , Fischer Sebastian , Gradhand Elise , Kunzmann Steffen , Zimmermann Stefanie Y. , Bakhtiar Shahrzad , Klingebiel Thomas , Schlösser Rolf , Lehrnbecher Thomas 

TITLE=Case Report: Symptomatic Chronic Granulomatous Disease in the Newborn

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.663883

DOI=10.3389/fimmu.2021.663883

ISSN=1664-3224

ABSTRACT=<p>Chronic granulomatous disease (CGD) is a primary immunodeficiency, which is diagnosed in most patients between one and three years of age. Here we report on a boy who presented at birth with extensive skin lesions and lymphadenopathy which were caused by CGD. An analysis of the literature revealed 24 patients with CGD who became symptomatic during the first six weeks of life. Although pulmonary complications and skin lesions due to infection were the leading symptoms, clinical features were extremely heterogenous. As follow-up was not well specified in most patients, the long-term prognosis of children with very early onset of CGD remains unknown.</p>