AUTHOR=Richardson Isaac M. , Calo Christopher J. , Hind Laurel E. TITLE=Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.661537 DOI=10.3389/fimmu.2021.661537 ISSN=1664-3224 ABSTRACT=
Neutrophils are the primary responders to infection, rapidly migrating to sites of inflammation and clearing pathogens through a variety of antimicrobial functions. This response is controlled by a complex network of signals produced by vascular cells, tissue resident cells, other immune cells, and the pathogen itself. Despite significant efforts to understand how these signals are integrated into the neutrophil response, we still do not have a complete picture of the mechanisms regulating this process. This is in part due to the inherent disadvantages of the most-used experimental systems: