AUTHOR=Li Siting , Song Guang , Bai Yina , Song Ning , Zhao Jiuliang , Liu Jian , Hu Chaojun TITLE=Applications of Protein Microarrays in Biomarker Discovery for Autoimmune Diseases JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.645632 DOI=10.3389/fimmu.2021.645632 ISSN=1664-3224 ABSTRACT=

Dysregulated autoantibodies and cytokines were deemed to provide important cues for potential illnesses, such as various carcinomas and autoimmune diseases. Increasing biotechnological approaches have been applied to screen and identify the specific alterations of these biomolecules as distinctive biomarkers in diseases, especially autoimmune diseases. As a versatile and robust platform, protein microarray technology allows researchers to easily profile dysregulated autoantibodies and cytokines associated with autoimmune diseases using various biological specimens, mainly serum samples. Here, we summarize the applications of protein microarrays in biomarker discovery for autoimmune diseases. In addition, the key issues in the process of using this approach are presented for improving future studies.