AUTHOR=Malaney Prerna , Velasco-Estevez María , Aguilar-Garrido Pedro , Aitken Marisa J. L. , Chan Lauren E. , Zhang Xiaorui , Post Sean M. , Gallardo Miguel 

TITLE=The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.634584

DOI=10.3389/fimmu.2021.634584

ISSN=1664-3224

ABSTRACT=<p>B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with the ultimate objective of identifying effective therapies. In this article, we discuss a new driver of B-cell lymphomas – hnRNP K (heterogenous nuclear ribonucleoprotein K)—an RNA-binding protein. We introduce the <italic>Eµ-Hnrnpk</italic> mouse model, a murine model characterized by hnRNP K overexpression in B cells, which develops B-cell lymphomas with high penetrance. Molecular analysis of the disease developed in this model reveals an upregulation of the <italic>c-Myc</italic> oncogene <italic>via</italic> post-transcriptional and translational mechanisms underscoring the impact of non-genomic <italic>MYC</italic> activation in B-cell lymphomas. Finally, the transplantability of the disease developed in <italic>Eµ-Hnrnpk</italic> mice makes it a valuable pre-clinical platform for the assessment of novel therapeutics.</p>