AUTHOR=Luque-Campos Noymar , Bustamante-Barrientos Felipe A. , Pradenas Carolina , García Cynthia , Araya María Jesús , Bohaud Candice , Contreras-López Rafael , Elizondo-Vega Roberto , Djouad Farida , Luz-Crawford Patricia , Vega-Letter Ana María 

TITLE=The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.624746

DOI=10.3389/fimmu.2021.624746

ISSN=1664-3224

ABSTRACT=<p>Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.</p>