AUTHOR=Telegin Georgii B. , Chernov Aleksandr S. , Kazakov Vitaly A. , Romanova Elena A. , Sharapova Tatiana N. , Yashin Denis V. , Gabibov Alexander G. , Sashchenko Lidia P. 

TITLE=A 8-mer Peptide of PGLYRP1/Tag7 Innate Immunity Protein Binds to TNFR1 Receptor and Inhibits TNFα-Induced Cytotoxic Effect and Inflammation

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.622471

DOI=10.3389/fimmu.2021.622471

ISSN=1664-3224

ABSTRACT=<p>Search for novel regulatory protein fragments with potential functional roles is required both for understanding the immune response mechanisms and the development of targeted immunotherapy. Earlier we demonstrated that the PGLYRP1/Tag7 innate immunity protein can be regarded as an inhibitor of TNFα cytotoxic activity <italic>via</italic> the interaction with its TNF receptor 1 (TNFR1). A C-terminal peptide fragment 17.1 of the molecule is responsible for this function. In this study we have identified a minimal 8-mer region of this peptide (hereinafter – 17.1A) capable to bind to TNFR1. As a result of such interaction, the cytot<bold>o</bold>xic signals induced by this receptor are blocked. Also, this peptide demonstrates an anti-inflammatory activity <italic>in vivo</italic> in the complete Freund’s adjuvant (CFA)-induced arthritis model in laboratory mice. Peptide 17.1A is capable to reduce periarticular inflammation, inhibit the development of synovitis and exhibit a protective effect on cartilage and bone tissues. This peptide can turn out to be a promising medicinal agent for autoimmune arthritis and other diseases.</p>