AUTHOR=French Timothy , Israel Nicole , Düsedau Henning Peter , Tersteegen Anne , Steffen Johannes , Cammann Clemens , Topfstedt Eylin , Dieterich Daniela , Schüler Thomas , Seifert Ulrike , Dunay Ildiko Rita TITLE=The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.619465 DOI=10.3389/fimmu.2021.619465 ISSN=1664-3224 ABSTRACT=
Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis. However, upon inflammation, the sharp increase in protein production requires additional mechanisms to limit protein-associated cellular stress. Under inflammatory conditions and the release of interferons, the immunoproteasome (IP) is induced to support protein processing and recycling. In antigen-presenting cells constitutively expressing IPs, inflammation-related mechanisms contribute to the formation of MHC class I/II-peptide complexes, which are required for the induction of T cell responses. The control of