AUTHOR=Wang Zhiding , Chen Jinghong , Wang Mengzhen , Zhang Linlin , Yu Li 

TITLE=One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.618710

DOI=10.3389/fimmu.2021.618710

ISSN=1664-3224

ABSTRACT=<p>T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions make Tim-3 a potential target for curing AML. This review mainly discusses the roles of Tim-3 in the immune system in AML and as an AML LSC marker, which sheds new light on the role of Tim-3 in AML immunotherapy.</p>