AUTHOR=Tran Florian , Schirmer Jan Henrik , Ratjen Ilka , Lieb Wolfgang , Helliwell Philip , Burisch Johan , Schulz Juliane , Schrinner Florian , Jaeckel Charlot , Müller-Ladner Ulf , Schreiber Stefan , Hoyer Bimba F. TITLE=Patient Reported Outcomes in Chronic Inflammatory Diseases: Current State, Limitations and Perspectives JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.614653 DOI=10.3389/fimmu.2021.614653 ISSN=1664-3224 ABSTRACT=

Chronic inflammatory diseases (CID) are emerging disorders which do not only affect specific organs with respective clinical symptoms but can also affect various aspects of life, such as emotional distress, anxiety, fatigue and quality of life. These facets of chronic disease are often not recognized in the therapy of CID patients. Furthermore, the symptoms and patient-reported outcomes often do not correlate well with the actual inflammatory burden. The discrepancy between patient-reported symptoms and objectively assessed disease activity can indeed be instructive for the treating physician to draw an integrative picture of an individual’s disease course. This poses a challenge for the design of novel, more comprehensive disease assessments. In this mini-review, we report on the currently available patient-reported outcomes, the unmet needs in the field of chronic inflammatory diseases and the challenges of addressing these.