AUTHOR=Cui Ming , Huang Jing , Zhang Shenghua , Liu Qiaofei , Liao Quan , Qiu Xiaoyan TITLE=Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.613530 DOI=10.3389/fimmu.2021.613530 ISSN=1664-3224 ABSTRACT=
Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region sequences and aberrant glycosylation. In contrast to B cell-derived Ig, which functions as an antibody in the humoral immune response, cancer-derived Ig exerts profound protumorigenic effects