AUTHOR=Meijer Mariska T. , de Vos Alex F. , Scicluna Brendon P. , Roelofs Joris J. , Abou Fayçal Chérine , Orend Gertraud , Uhel Fabrice , van der Poll Tom TITLE=Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.600979 DOI=10.3389/fimmu.2021.600979 ISSN=1664-3224 ABSTRACT=
Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC−/−) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we investigated the role of TNC during gram-negative pneumonia derived sepsis. TNC+/+ and TNC−/− mice were infected with