AUTHOR=Li Shuping , Wang Xiaohua , Zhao Yuming , Yang Juan , Cui Tianjiao , Zhao Zhizhuang Joe , Chen Yun , Zheng Zhihua 

TITLE=Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.592841

DOI=10.3389/fimmu.2021.592841

ISSN=1664-3224

ABSTRACT=<p>It was previously published that single-nucleotide polymorphism rs2476601 (<italic>PTPN22</italic> [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to <italic>Mycobacterium tuberculosis</italic> and <italic>M. leprae</italic> infection. However, the results were inconclusive despite a high degree of similarity between both parameters. Herein, we carried out this meta-analysis to systematically summarize and articulate the correlation between <italic>PTPN22</italic>-C1858T polymorphism and mycobacterial infection. The susceptibility of <italic>PTPN22</italic>-C1858T carriers with autoimmune conditions receiving immunosuppressive therapy to <italic>M. tuberculosis</italic> and <italic>M. leprae</italic> infection was determined. A systematic retrieval of studies on relevance of <italic>PTPN22</italic>-C1858T polymorphism to susceptibility of <italic>M. tuberculosis</italic> or <italic>M. leprae</italic> infection was performed in Chinese National Knowledge Infrastructure, PubMed and Embase databases. We regarded Odds ratios (ORs) and 95% confidence intervals (CIs) as the determined effect size. Finally, four and two case-control studies on tuberculosis and leprosy, respectively, were included. In all genetic models, without indicated association between <italic>PTPN22</italic>-C1858T polymorphism and tuberculosis’s susceptibility. [C versus T: OR = 0.22 (95% CI: 0.09–0.50, P<sub>H</sub> = 0.887); CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, P<sub>H</sub> = 0.889); TT+CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, P<sub>H</sub> = 0.889)]. A significantly increased risk of leprosy was perceived in patients with the <italic>PTPN22</italic>-C1858T polymorphism [C versus T: OR = 2.82 (95% CI: 1.02–7.81, P<sub>H</sub> = 0.108)]. While the <italic>PTPN22</italic>-C1858T polymorphism is irrelevant to higher susceptibility to the infection of <italic>M. tuberculosis</italic> in Caucasians and Asians, it is relevant to increased susceptibility to the infection of <italic>M. leprae</italic>. However, the results of <italic>M. leprae</italic> are supposed to interpreted with prudence owing to the limited quantity of studies and heterogeneity. Further well-designed studies with sufficient populations are required to verify our conclusions.</p>