AUTHOR=Silva-Junior Alexander Leonardo , Garcia Nadja Pinto , Cardoso Evilázio Cunha , Dias Stephanny , Tarragô Andrea Monteiro , Fraiji Nelson Abrahim , Gomes Matheus Souza , Amaral Laurence Rodrigues , Teixeira-Carvalho Andréa , Martins-Filho Olindo Assis , De Paula Erich Vinicius , Costa Allyson Guimarães , Malheiro Adriana TITLE=Immunological Hallmarks of Inflammatory Status in Vaso-Occlusive Crisis of Sickle Cell Anemia Patients JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.559925 DOI=10.3389/fimmu.2021.559925 ISSN=1664-3224 ABSTRACT=
Sickle Cell Anemia (SCA) is the most common genetic disorder around the world. The mutation in the β-globin gene is responsible for a higher hemolysis rate, with further involvement of immunological molecules, especially cytokines, chemokines, growth factors, and anaphylatoxins. These molecules are responsible for inducing and attracting immune cells into circulation, thus contributing to increases in leukocytes and other pro-inflammatory mediators, and can culminate in a vaso-occlusive crisis (VOC). This study aimed to characterize the levels of these molecules in SCA patients in different clinical conditions in order to identify potential hallmarks of inflammation in these patients. An analytical prospective study was conducted using the serum of SCA patients in steady-state (StSt;