AUTHOR=Mora-Buch Rut , Bromley Shannon K. 

TITLE=Discipline in Stages: Regulating CD8+ Resident Memory T Cells

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.624199

DOI=10.3389/fimmu.2020.624199

ISSN=1664-3224

ABSTRACT=<p>Resident memory CD8<sup>+</sup> T (T<sub>RM</sub>) cells are a lymphocyte lineage distinct from circulating memory CD8<sup>+</sup> T cells. T<sub>RM</sub> lodge within peripheral tissues and secondary lymphoid organs where they provide rapid, local protection from pathogens and control tumor growth. However, dysregulation of CD8<sup>+</sup> T<sub>RM</sub> formation and/or activation may contribute to the pathogenesis of autoimmune diseases. Intrinsic mechanisms, including transcriptional networks and inhibitory checkpoint receptors control T<sub>RM</sub> differentiation and response. Additionally, extrinsic stimuli such as cytokines, cognate antigen, fatty acids, and damage signals regulate T<sub>RM</sub> formation, maintenance, and expansion. In this review, we will summarize knowledge of CD8<sup>+</sup> T<sub>RM</sub> generation and highlight mechanisms that regulate the persistence and responses of heterogeneous T<sub>RM</sub> populations in different tissues and distinct microenvironments.</p>