Corrigendum: Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation

A Corrigendum on
Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation

By Han J-H, Cai M, Grein J, Perera S, Wang H, Bigler M, Ueda R, Rosahl TW, Pinheiro E, LaFace D, Seghezzi W and Williams SMG. Front. Immunol. (2020) 11:573405. doi: 10.3389/fimmu.2020.573405

In the original article, there was a mistake in Figure 6 as published. While upgrading the figure with a high resolution for publication, the “on-figure” legend describing each experimental group was depicted inconsistently from the rest of the article. The corrected Figure 6 appears below.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

FIGURE 6

Figure 6 Enhanced immune activation in tumors by anti-PD-1 can be achieved only when anti-TIGIT antibody has a functional Fc. (A–I) In order to gain molecular insights of anti-PD-1 and anti-TIGIT combination for anti-tumor responses, anti-PD-1 in the presence or absence of anti-TIGIT with mIgG1* or mIgG2a isotype were therapeutically treated in CT26 tumor-bearing mice. Four days after the second dose of each group (n = 10 per group), all the tumors were isolated and processed for real-time PCR. Relative gene expression profile of (A) CD45, (B) CD3+, (C) CD11b, (D) CD3+/CD11b ratio, (E) CD8b, (F) Foxp3, (G) IFN-g, (H) Perforin, and (I) Granzyme B. (J, K) In an independent experiment, indicated antibody regimen were injected to CT26 tumor-bearing mice every 4 days. The whole tumors were harvested untreated (day 0), 2 days after first injection (day 2), 4 days after first injection (day 4), 2 days after second injection (day 6), and 4 days after second injection (day 8). Each symbol represents average and standard error of 10 tumors from each group at each time point for the analysis of (J) Perforin and (K) Granzyme B. Orange arrow heads indicate the time points of antibody treatments. ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001.