AUTHOR=Duhan Vikas , Khairnar Vishal , Kitanovski Simo , Hamdan Thamer A. , Klein Andrés D. , Lang Judith , Ali Murtaza , Adomati Tom , Bhat Hilal , Friedrich Sarah-Kim , Li Fanghui , Krebs Philippe , Futerman Anthony H. , Addo Marylyn M. , Hardt Cornelia , Hoffmann Daniel , Lang Philipp A. , Lang Karl S. 

TITLE=Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.607889

DOI=10.3389/fimmu.2020.607889

ISSN=1664-3224

ABSTRACT=<p>Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (<italic>Itgae</italic>, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.</p>