AUTHOR=Suen Jau-Ling , Wu Tai-Ting , Li Yue-Hyuan , Lee Chin-Lai , Kuo Fu-Chen , Yan Pearlly S. , Wu Chia-Fang , Tran Mita , Wang Chien-Jen , Hung Chih-Hsing , Wu Ming-Tsang , Chan Michael W. Y. , Huang Shau-Ku TITLE=Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells JOURNAL=Frontiers in Immunology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.603831 DOI=10.3389/fimmu.2020.603831 ISSN=1664-3224 ABSTRACT=
The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its underlying mechanism remain unknown. This study explored the transgenerational mechanism of DEHP on allergic asthma and dendritic cell (DC) homeostasis through epigenetic modification. In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the