AUTHOR=Cenciarelli Sabina , Calbi Valeria , Barzaghi Federica , Bernardo Maria Ester , Oltolini Chiara , Migliavacca Maddalena , Gallo Vera , Tucci Francesca , Fraschetta Federico , Albertazzi Elena , Fratini Elena Sophia , Consiglieri Giulia , Giannelli Stefania , Dionisio Francesca , Sartirana Claudia , Racca Sara , Camesasca Chiara , Peretto Giovanni , Daverio Rita , Esposito Antonio , De Cobelli Francesco , Silvani Paolo , Rabusin Marco , Cara Andrea , Trabattoni Daria , Dispinseri Stefania , Scarlatti Gabriella , Piemonti Lorenzo , Lampasona Vito , Cicalese Maria Pia , Aiuti Alessandro , Ferrua Francesca TITLE=Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report JOURNAL=Frontiers in Immunology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.603428 DOI=10.3389/fimmu.2020.603428 ISSN=1664-3224 ABSTRACT=

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.