AUTHOR=Li Lili , Li Jie , Gao Meiling , Fan Huimin , Wang Yanan , Xu Xin , Chen Chunfeng , Liu Junxiao , Kim Jocelyn , Aliyari Roghiyh , Zhang Jicai , Jin Yujie , Li Xiaorong , Ma Feng , Shi Minxin , Cheng Genhong , Yang Heng TITLE=Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients JOURNAL=Frontiers in Immunology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.602395 DOI=10.3389/fimmu.2020.602395 ISSN=1664-3224 ABSTRACT=

The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.