AUTHOR=Abu-Raya Bahaa , Michalski Christina , Sadarangani Manish , Lavoie Pascal M. 

TITLE=Maternal Immunological Adaptation During Normal Pregnancy

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.575197

DOI=10.3389/fimmu.2020.575197

ISSN=1664-3224

ABSTRACT=<p>The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.</p>