AUTHOR=Safarzadeh Elham , Asadzadeh Zahra , Safaei Sahar , Hatefi Arash , Derakhshani Afshin , Giovannelli Francesco , Brunetti Oronzo , Silvestris Nicola , Baradaran Behzad 

TITLE=MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.572323

DOI=10.3389/fimmu.2020.572323

ISSN=1664-3224

ABSTRACT=<p>Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in several abnormal physiological conditions such as cancer. Recently, novel regulatory tumor MDSC biology modulating mechanisms, including differentiation, expansion and function, were defined. There is growing evidence that miRNAs and long non-coding RNAs (lncRNA) are involved in modulating transcriptional factors to become complex regulatory networks that regulate the MDSCs in the tumor microenvironment. It is possible that aberrant expression of miRNAs and lncRNA contributes to MDSC biological characteristics under pathophysiological conditions. This review provides an overview on miRNAs and lncRNAs epiregulation of MDSCs development and immunosuppressive functions in cancer.</p>