AUTHOR=Domnich Maksim , Riedesel Jana , Pylaeva Ekaterina , Kürten Cornelius H. L. , Buer Jan , Lang Stephan , Jablonska Jadwiga 

TITLE=Oral Neutrophils: Underestimated Players in Oral Cancer

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.565683

DOI=10.3389/fimmu.2020.565683

ISSN=1664-3224

ABSTRACT=<p>The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for oral pathologies. This review focuses on salivary neutrophils in the oral cavity, their phenotype changes in physiological and pathological conditions, as well as on factors regulating oral neutrophil amount, activation and functionality, with special emphasis on oral cancer and its risk factors.</p>