AUTHOR=Amadou Amani Souwelimatou , Lang Mark L. 

TITLE=Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.565648

DOI=10.3389/fimmu.2020.565648

ISSN=1664-3224

ABSTRACT=<p>Bacterial enteric pathogens individually and collectively represent a serious global health burden. Humoral immune responses following natural or experimentally-induced infections are broadly appreciated to contribute to pathogen clearance and prevention of disease recurrence. Herein, we have compared observations on humoral immune mechanisms following infection with <italic>Citrobacter rodentium</italic>, the model for enteropathogenic <italic>Escherichia coli, Vibrio cholerae, Shigella</italic> species<italic>, Salmonella enterica</italic> species, and <italic>Clostridioides difficile</italic>. A comparison of what is known about the humoral immune responses to these pathogens reveals considerable variance in specific features of humoral immunity including establishment of high affinity, IgG class-switched memory B cell and long-lived plasma cell compartments. This article suggests that such variance could be contributory to persistent and recurrent disease.</p>