AUTHOR=Pastar Irena , O’Neill Katelyn , Padula Laura , Head Cheyanne R. , Burgess Jamie L. , Chen Vivien , Garcia Denisse , Stojadinovic Olivera , Hower Suzanne , Plano Gregory V. , Thaller Seth R. , Tomic-Canic Marjana , Strbo Natasa TITLE=Staphylococcus epidermidis Boosts Innate Immune Response by Activation of Gamma Delta T Cells and Induction of Perforin-2 in Human Skin JOURNAL=Frontiers in Immunology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.550946 DOI=10.3389/fimmu.2020.550946 ISSN=1664-3224 ABSTRACT=
Perforin-2 (P-2) is an antimicrobial protein with unique properties to kill intracellular bacteria. Gamma delta (GD) T cells, as the major T cell population in epithelial tissues, play a central role in protective and pathogenic immune responses in the skin. However, the tissue-specific mechanisms that control the innate immune response and the effector functions of GD T cells, especially the cross-talk with commensal organisms, are not very well understood. We hypothesized that the most prevalent skin commensal microorganism,